Anti-Aging Cos&Beauty

Unveiling Anti-Aging Tech: Billionaires’ Picks & New Ingredients

The process of aging is a cruel but inevitable law of human survival. In ancient times, emperors pursued the “elixir of immortality,” and today, super-rich individuals are “madly” investing in life sciences and anti-aging research.

In 2022, former world’s richest person Jeff Bezos and Russian tycoon Yuri Milner invested $3 billion in the U.S. startup Altos Labs, dedicated to anti-aging research. Sam Altman, the founder of ChatGPT, also invested $180 million to establish Retro Biosciences, a company focused on anti-aging technologies and researching ways to extend human lifespan.

According to the “2023 Insight Report on Middle-aged and Elderly Health Food” released by Magic Mirror, as China enters an aging society, people’s attention and demand for anti-aging have deepened. The sales of middle-aged and elderly health food on Tmall Taobao in 2023 reached 9.81 billion yuan, a year-on-year increase of 55%, indicating a growing consumer interest.

Amid the demand for anti-aging, what technologies do super-rich individuals prioritize? And which ingredients are the highly anticipated “new stars” in anti-aging?

Image source: unsplash

Technologies Targeted by the Wealthy

1. Cellular Reprogramming

  • Altos Labs: Backed by Bezos, Altos Labs has a formidable team, including chief scientists from pharmaceutical giant GSK and four Nobel laureates. Their core goal is to establish a “cellular reprogramming technology” to induce pluripotent stem cells and embryonic stem cells to possess “regenerative” abilities, reversing the aging process.
  • Retro Biosciences: This company focuses on cellular reprogramming, autophagy, plasma-related therapies, and aims to “extend human life by ten years.” It has received investment from the founder of ChatGPT.

2. Anti-Aging Drug Development

Anti-aging drugs have significant potential, mainly targeting aging and damaged genes. “Senolytics,” a drug targeting senescent cells, has been confirmed by European research teams to positively impact diseases like cataracts, diabetes, and heart failure by inducing the death of aging cells.

3. Nutritional Supplements

In 2021, the global anti-aging market reached $216 billion. In China, 62.4% of consumers use facial and internal anti-aging products, with 48.4% being internal. Products focus on ingredients like grape seed extract, PQQ, NMN, astaxanthin, and lycopene.

American MAAC high-purity NMN supplement

For example, NMN is a crucial NAD+ supplement with anti-aging effects, while fisetin and ergothioneine are other notable ingredients gaining attention for their anti-aging properties.

Fisetin: Targeting Senescent Cells

Fisetin, also known as fisetin acid, fisetinol, or hydroxyflavone, is a yellow needle-shaped crystal naturally found in the lacquer tree of the Rhus family. It is also present in various common foods like strawberries, apples, persimmons, and onions.

![Doctor’s Best Fisetin Vegetarian Capsules](source: Amazon)

The “Compendium of Materia Medica” records that leaves containing fisetin can alleviate irritability, treat alcohol-related jaundice, and, when boiled, can be used to treat jaundice-type hepatitis. Fisetin exhibits pharmacological effects against various pathological processes, with epidemiological studies suggesting that regular consumption of flavonoid-rich fruits and vegetables can reduce the risk of diseases such as cardiovascular diseases, inflammatory conditions, neurodegenerative diseases, and cancer.

  • Antioxidant: Fisetin’s chemical structure includes flavonoid polyphenols, providing excellent antioxidant effects. Its ability to clear free radicals depends on polyphenol oxidase.
  • Anti-inflammatory: Fisetin’s anti-inflammatory properties manifest in 1) inhibiting the activity of inflammatory cells like neutrophils, macrophages, and mast cells, and 2) suppressing the expression of inflammatory mediators, effectively inhibiting inflammation responses in animal models of stress-induced kidney injury, hepatitis, acute lung injury, and acute otitis media.
  • Anti-aging: The World Health Organization (WHO) explains that aging, at the biological level, results from the accumulation of molecular and cellular damage over time. This leads to a gradual decline in physical and mental capabilities, an increased risk of diseases, and ultimately death. Fisetin primarily clears senescent cells by inducing apoptosis, reducing the interference of aging cells with healthy cells, thereby avoiding the “silent” outbreak of more significant chronic diseases.
German Hepatica Fisetin Capsules
German Hepatica Fisetin Capsules

The renowned Mayo Clinic in the United States has been dedicated to researching fisetin. Since its discovery in 2018 for its ability to extend the lifespan of aging mice, various articles confirming its efficacy have been published in the journal “EBioMedicine.”

Recently, the Mayo Clinic released the latest research results on fisetin, demonstrating its ability to restore tissue stability and alleviate related pathological symptoms in late-life wild-type mice.

Ergothioneine: A New Breakthrough in Oral Beauty

Ergothioneine (EGT), also known as thioneine, is a natural sulfur-containing amino acid with potent antioxidant properties. Initially isolated by Tanret from the ergot fungus Claviceps purpurea in rye grass, ergothioneine is mainly found in edible and medicinal mushrooms.

Given its strong antioxidant, high stability, and non-toxic characteristics, ergothioneine holds promising applications in the field of biomedicine, demonstrating excellence in antioxidant, anti-inflammatory, neuroprotective, cardiovascular protection, and liver disease prevention.

GeneIII Ergothioneine Capsules
  • Antioxidant: Ergothioneine can eliminate reactive oxygen species (ROS) both inside and outside the body. It binds to free electrons of hydroxyl radicals, hypochlorite ions, singlet oxygen, and peroxynitrite, exhibiting powerful free radical scavenging capabilities comparable to recognized antioxidants such as glutathione and ascorbic acid.
  • Anti-inflammatory: Inflammatory factors in inflammation reactions induce various diseases, and excessive inflammation can damage cells, tissues, and organs. Ergothioneine can effectively inhibit the activation of inflammatory factors, slowing their release, transcription, and expression.
  • Neuroprotection: Research indicates that ergothioneine can regulate neuron differentiation, neurogenesis, and microglial cell activation by crossing the blood-brain barrier. It can also prevent neurotoxicity caused by pathogenic proteins or chemicals, making it valuable for preventing neurodegenerative diseases.

In 2017, 2019, and 2021, ergothioneine was approved for use in health supplements and general food in Europe, the United States, and Japan, respectively. In 2014, China’s National Medical Products Administration included ergothioneine in the “Catalogue of Cosmetics Ingredients Used in China.”

Ergothioneine is rare in nature, with one strain of shiitake mushrooms containing only 0.01% ergothioneine. Its scarcity is reflected in its price, which is comparable to that of gold.

As an example, Swisse recently launched the “Ergothioneine Super Glow Bottle.” Each capsule contains 1.6mg of ergothioneine, along with 40mg of hyaluronic acid and 833mg of collagen, aiming to achieve a tightened skin contour, increased skin hydration, and reduced wrinkles.

You may also like...

Leave a Reply

Your email address will not be published. Required fields are marked *